Quarfloxin

Izina ryimiti:

5-fluoro-N- (2 - ((S) -1-methylpyrrolidin-2-yl) ethyl) -3-oxo-6 - ((R) -3- (pyrazin-2-yl) pyrrolidin-1-yl ) -3H-benzo [b] pyrido [3,2,1-kl] phenoxazine-2-carboxamide

Kode ya SMILES:

FC1 = C (N2CC [C @@ H] (C3 = CN = CC = N3) C2) C (OC4 = C5C = C6C (C = CC = C6) = C4) = C (N5C = C (C (NCC [ C @ H] 7N (C) CCC7) = O) C8 = O) C8 = C1

InChi Code:

InChI = 1S / C35H33FN6O3 / c1-40-13-4-7-24 (40) 8-10-39-35 (44) 26-20-42-29-15-21-5-2-3-6- 22 (21) 16-30 (29) 45-34-31 (42) 25 (33 (26) 43) 17-27 (36) 32 (34) 41-14-9-23 (19-41) 28- 18-37-11-12-38-28 / h2-3,5-6,11-12,15-18,20,23-24H, 4,7-10,13-14,19H2,1H3, (H , 39,44) / t23-, 24 + / m1 / s1

InChi Urufunguzo:

WOQIDNWTQOYDLF-RPWUZVMVSA-N

Ijambo ryibanze:

CX 3543; CX-3543; CX 3543; Quarfloxacin

Gukemura: 

Ububiko: 

Ibisobanuro:

Quarfloxin, izwi kandi nka Quarfloxacin na CX-3543, ikomoka kuri fluoroquinolone ikomoka ku bikorwa bya antineoplastique. Quarfloxin ihagarika imikoranire hagati ya poroteyine nucleolin na ADN ya G-quadruplex mu gishushanyo cya ADN ya ribosomal (rDNA), imikoranire ikomeye kuri biogenezi ya rRNA ikabije cyane mu ngirabuzimafatizo za kanseri; ihungabana ryiyi G-quadruplex ADN: imikoranire ya poroteyine muri aberrant rRNA biogenezi irashobora gutuma habaho guhagarika synthesis ya ribosome na selile apoptose.

Intego: