| CAT # | Izina ryibicuruzwa | Ibisobanuro |
| CPD100608 | BAZA-Inhibitor-10 | ASK1 Inhibitor 10 ni bioavailable yo mu kanwa inhibitor ya apoptose ibimenyetso-bigenga kinase 1 (ASK1). Ihitamo kuri ASK1 hejuru ya ASK2 kimwe na MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, na B-RAF. Irabuza kwiyongera kwa streptozotocine iterwa na JNK na p38 fosifora muri selile INS-1 pancreatic β selile muburyo bushingiye kumitekerereze. |
| CPD100607 | K811 | K811 ni ASK1 yihariye inhibitor yongerera igihe cyo kubaho muburyo bwimbeba ya amyotrophique lateral sclerose. K811 yabujije neza gukwirakwiza selile mumirongo ya selile hamwe nimvugo ndende ya ASK1 no muri HER2-ikabije cyane ingirabuzimafatizo za GC. Umuti hamwe na K811 wagabanije ubunini bwibibyimba bya xenograft mugabanya ibimenyetso byikwirakwizwa. |
| CPD100606 | K812 | K812 ni inhibitor ya ASK1 yavumbuwe kugirango irambe kuramba muburyo bwimbeba ya amyotrophique lateral sclerose. |
| CPD100605 | MSC-2032964A | MSC 2032964A ninzitizi ikomeye kandi ihitamo ASK1 inhibitor (IC50 = 93 nM). Ihagarika LPS iterwa na ASK1 na p38 fosifora muri astrocytes yimbeba yimico kandi ikumira neuroinflammation muburyo bwimbeba EAE. MSC 2032964A ni munwa bioavailable kandi yinjira mubwonko. |
| CPD100604 | Selonsertib | Selonsertib, izwi kandi ku izina rya GS-4997, ni bioavailable yo mu kanwa ya inhibitor ya signal ya apoptose igenga kinase 1 (ASK1), hamwe nibikorwa bishobora kurwanya inflammatory, antineoplastique na anti-fibrotic. Intego ya GS-4997 kandi ihuza na catalitike ya kinase ya ASK1 muburyo bwa ATP irushanwa, bityo ikabuza fosifora no gukora. GS-4997 irinda umusaruro wa cytokine ikongora, igabanya-imiterere ya gen zigira uruhare muri fibrosis, ikumira apoptose ikabije kandi ikabuza ikwirakwizwa rya selile. |
