| CAT # | Izina ryibicuruzwa | Ibisobanuro |
| CPD100603 | MDK36122 | MDK36122, izwi kandi nka H-PGDS Inhibitor I, ni Prostaglandin D Synthase (ubwoko bwa hematopoietic). MDK36122 nta zina rya code ifite, kandi ifite CAS # 1033836-12-2. Imibare 5 yanyuma yakoreshejwe mwizina ryitumanaho ryoroshye. MDK36122 ihitamo guhitamo HPGDS (IC50s = 0.7 na 32 nM muri enzyme na selile selile) hamwe nibikorwa bike birwanya imisemburo yabantu ifitanye isano L-PGDS, mPGES, COX-1, COX-2, na 5-LOX. |
| CPD100602 | Tepoxalin | Tepoxalin, izwi kandi nka ORF-20485; RWJ-20485; ni 5-lipoxygenase inhibitor ishobora kuvura asima, osteoarthritis (OA). Tepoxalin ifite ibikorwa byo kubuza vivo kurwanya COX-1, COX-2, na 5-LOX mu mbwa kuri dosiye yemewe ubu. Tepoxalin yongera ibikorwa bya antioxydeant, pyrrolidine dithiocarbamate, muguhuza ibibyimba bya nekrosis yibintu alpha-iterwa na apoptose muri selile WEHI 164. |
| CPD100601 | Tenidap | Tenidap, izwi kandi ku izina rya CP-66248, ni inhibitor ya COX / 5-LOX hamwe n’umukandida w’imiti igabanya ubukana bwa cytokine-moduline yari irimo gutezwa imbere na Pfizer nk'umuti ushobora kuvura indwara ya rubagimpande, ariko Pfizer yahagaritse iterambere nyuma yo kwemererwa kwamamaza. na FDA mu 1996 kubera uburozi bwumwijima nimpyiko, byatewe na metabolite yibiyobyabwenge hamwe na thiophene moiety yangiza okiside. |
| CPD100600 | PF-4191834 | PF-4191834 nigitabo gishya, gikomeye kandi cyatoranijwe kitari redox 5-lipoxygenase inhibitor ikora neza mugutwika no kubabara. PF-4191834 yerekana imbaraga nziza muri enzyme- na selile zishingiye ku ngirabuzimafatizo, ndetse no muburyo bw'imbeba yo gutwika gukabije. Ibisubizo bya Enzyme byerekana ko PF-4191834 ari inhibitor ikomeye 5-LOX, hamwe na IC (50) = 229 +/- 20 nM. Byongeye kandi, yerekanye guhitamo inshuro zigera kuri 300 kuri 5-LOX hejuru ya 12-LOX na 15-LOX kandi ntigaragaza ibikorwa bijyanye na enzymes ya cyclooxygenase. Byongeye kandi, PF-4191834 ibuza 5-LOX mu ngirangingo z'amaraso y'abantu, hamwe na IC (80) = 370 +/- 20 nM. |
| CPD100599 | MK-886 | MK-886, izwi kandi nka L 663536, ni antagonist leukotriene. Irashobora kubikora muguhagarika 5-lipoxygenase ikora proteine (FLAP), bityo ikabuza 5-lipoxygenase (5-LOX), kandi irashobora gufasha mukuvura aterosklerose. MK-886 ibuza ibikorwa bya cyclooxygenase-1 kandi ikabuza gukusanya platine. MK-886 itera impinduka mumuzunguruko kandi ikongera apoptose nyuma yo kuvura Photodynamic hamwe na hypericine. MK-886 yongerera ikibyimba necrosis factor-alpha iterwa no gutandukana na apoptose. |
| CPD100598 | L-691816 | L 691816 ni inhibitor ikomeye ya reaction ya 5-LO haba muri vitro ndetse no muburyo bwa vivo. |
| CPD100597 | CMI-977 | CMI-977, izwi kandi nka LPD-977 na MLN-977, ni inibitori ikomeye ya lipoxygenase 5 yivanga mu musaruro wa leukotriène kandi ubu irimo gutezwa imbere mu kuvura asima idakira. CMI-977 ibuza inzira ya 5-lipoxygenase (5-LO) inzira yo gutwika ingirabuzimafatizo kugirango ibuze ibisekuruza bya leukotriène, bigira uruhare runini mu gutera asima ya bronhia. |
| CPD100596 | CJ-13610 | CJ-13610 ni inzitizi ikora mu kanwa ya 5-lipoxygenase (5-LO). CJ-13610 ibuza biosynthesis ya leukotriene B4 kandi igenga imvugo ya IL-6 mRNA muri macrophage. Nibyiza muburyo bwa preclinical ububabare. |
| CPD100595 | BRP-7 | BRP-7 ni 5-LO ikora poroteyine (FLAP) inhibitor. |
