Ingliforib

Izina ryimiti:

5-chloro-N - ((2S, 3R) -4 - ((3S, 4R) -3,4-dihydroxypyrrolidin-1-yl) -3-hydroxy-4-oxo-1-fenylbutan-2-yl) - 1H-indole-2-carboxamide

Kode ya SMILES:

O [C @ H] (C1) [C @ @ H] (O) CN1C ([C @ H] (O) [C @ H] (CC2 = CC = CC = C2) NC (C3 = CC4 = C N3) C = CC (Cl) = C4) = O) = O.

InChi Code:

InChI = 1S / C23H24ClN3O5 / c24-15-6-7-16-14 (9-15) 10-18 (25-16) 22 (31) 26-17 (8-13-4-2-1-3- 5-13) 21 (30) 23 (32) 27-11-19 (28) 20 (29) 12-27 / h1-7,9-10,17,19-21,25,28-30H, 8, 11-12H2, (H, 26,31) / t17-, 19-, 20 +, 21 + / m0 / s1

InChi Urufunguzo:

GVDRRZOORHCTAN-MJUUVYJYSA-N

Ijambo ryibanze:

Ingliforib; CP-296; CP-368; CP-368.296; CP296; CP 296; CP-368296; CP368296; CP 368296

Gukemura:DMSO

Ububiko: 

Ibisobanuro:

Ingliforib, izwi kandi nka CP-368296, ni igitabo cyitwa glycogene phosphorylase inhibitor. Ingliforib ifite antihyperglycemic na cardioprotective. Ingliforib ibuza fosifori ya glycogene, enzyme igabanya umuvuduko muri glycogenolysis, bityo ikabuza kurekura fosifike glucose-1 muri molekile ya glycogene mu mwijima. Iyi miti kandi irabuza fosifori ya glycogene mumitsi yumutima kandi irashobora kurinda umutima gukomeretsa ischemic myocardial mukurinda glycogene no kunoza glycolytike-okiside.

Intego: glycogene fosifora