IACS-010759

Izina ryimiti:

5- (5-methyl-1- (3- (4- (methylsulfonyl) piperidin-1-yl) benzyl) -1H-1,2,4-triazol-3-yl) -3- (4- (trifluoromethoxy) fenyl) -1,2,4-oxadiazole

Kode ya SMILES:

FC (F) (F) OC1 = CC = C (C2 = NOC (C3 = NN (CC4 = CC = CC (N5CCC (S (= O) (C) = O) CC5) = C4) C (C) = N3) = N2) C = C1

InChi Code:

InChI = 1S / C25H25F3N6O4S / c1-16-29-23 (24-30-22 (32-38-24) 18-6-8-20 (9-7-18) 37-25 (26,27) 28) 31-34 (16) 15-17-4-3-5-19 (14-17) 33-12-10-21 (11-13-33) 39 (2,35) 36 / h3-9,14, 21H, 10-13,15H2,1-2H3

InChi Urufunguzo:

HWJWNWZJUYCGKV-UHFFFAOYSA-N

Ijambo ryibanze:

IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

IACS-010759 cyangwa IACS-10759 ni imbaraga zikomeye kandi zitoranya Oxidative Phosphorylation Inhibitor (IC50<10 nM) hamwe nibikorwa bya antineoplastique. IACS-010759 ihuza kandi ikabuza urwego rwa I rwurwego rwo gutwara ibintu bya elegitoronike (NADH ubiquinone oxidoreductase), bityo bikabura guhitamo ingirabuzimafatizo yibibyimba byintungamubiri, ningufu, kandi bikabuza umusaruro wa nucleotide na aside amine, bitera autofagy, bikabuza urupfu rwibibyimba kandi bikabuza selile. ikwirakwizwa. Uruganda rwa Mitochondrial I, rufite imbaraga nyinshi mu ngirabuzimafatizo za kanseri kugira ngo rushobore gukenera ingufu, rufite uruhare runini mu kuzamura ikwirakwizwa rya kanseri.

Intego: OXPHOS