BMS-986195

Izina ryimiti:

(S) -4- (3 -

Kode ya SMILES:

FC1 = C (N2CCC [C @ H] (NC (C # CC) = O) C2) C3 = C (NC (C) = C3C) C (C (N) = O) = C1

InChi Code:

InChI = 1S / C20H23FN4O2 / c1-4-6-16 (26) 24-13-7-5-8-25 (10-13) 19-15 (21) 9-14 (20 (22) 27) 18- 17 (19) 11 (2) 12 (3) 23-18 / h9,13,23H, 5,7-8,10H2,1-3H3, (H2,22,27) (H, 24,26) / t13 - / m0 / s1

InChi Urufunguzo:

VJPPLCNBDLZIFG-ZDUSSCGKSA-N

Ijambo ryibanze:

BMS-986195, BMS 986195, BMS986195, 1912445-55-6

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

BMS-986195 ni inzitizi ikomeye, ihindagurika, idasubirwaho ya Bruton ya tyrosine kinase (BTK), umwe mu bagize umuryango wa Tec wa reseptor tyrosine kinase idakenewe cyane mu bimenyetso bya B-selile biterwa na antigen. BMS-986195 ni inshuro zirenga 5000 zatoranijwe kuri BTK hejuru ya kinase zose hanze yumuryango wa Tec, kandi guhitamo kuva kuri 9 kugeza 1010 mumuryango wa Tec. BMS-986195 idakora BTK mumaraso yumuntu yose hamwe nigipimo cyihuse cyo kudakora (3.5 × 10-4 nM-1 · min-1) kandi ihagarika cyane umusaruro wa interleukin-6 iterwa na antigen, imvugo ya CD86 no gukwirakwira muri selile B (IC50<1 nM) nta ngaruka ku ngamba zigenga antigen muri selile imwe.

Intego: BTK