BI-2852

Izina ryimiti:

(S) -5-hydroxy-3- (2 - (((((1 - (((1 -1H-indol-3-yl) isoindolin-1-imwe

Kode ya SMILES:

OC (C = C1) = CC ([C @@ H] (C2 = C (CNCC3 = CC4 = C (C = CN4CC5 = CN (C) C = N5) C = C3) NC6 = CC = CC = C62) N7) = C1C7 = O.

InChi Code:

InChI = 1S / C31H28N6O2 / c1-36-16-21 (33-18-36) 17-37-11-10-20-7-6-19 (12-28 (20) 37) 14-32-15- 27-29 (24-4-2-3-5-26 (24) 34-27) 30-25-13-22 (38) 8-9-23 (25) 31 (39) 35-30 / h2- 13,16,18,30,32,34,38H, 14-15,17H2,1H3, (H, 35,39) / t30- / m0 / s1

InChi Urufunguzo:

JYEQLXOWWLNVDX-PMERELPUSA-N

Ijambo ryibanze:

Gukemura: 

Ububiko: 

Ibisobanuro:

BI-2852 ninzitizi ikomeye ya KRAS ihuza na nanomolar ifitanye isano nu mufuka, kugeza ubu ikaba ibona ko "idashobora gukururwa," hagati ya switch I na II kuri RAS. BI-2852 itandukanijwe muburyo bwa tekinike na covalent KRASG12C inhibitor kuko ihuza umufuka utandukanye uboneka muburyo bukora kandi budakora bwa KRAS. BI-2852 ihagarika GEF, GAP, hamwe na effektor ikorana na KRAS, biganisha ku kubuza amarenga yo hepfo no kurwanya antiproliferative muri selile mutant ya KRAS.

Intego: KRAS