S-600918,Sivopixant

Navê Kîmyayî:

(2S)-3-[(4E)-3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-({4-[(pyridin-2-yl)oxy]fenyl}imino)-1 ,3,5-triazinan-1-yl]-2-methylpropanoic acid

Koda SMILES:

O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC =CC=C4)C=C3)=O

Koda InChi:

InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17)28-19-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H ,32,33)(H,28,29,34)/t16-/m0/s1

Bişkojka InChi:

SKZQFKBIJUXXCG-INIZCTEOSA-N

Keyword:

2414285-40-6; CAS:2414285-40-6; CAS：2414285-40-6; Sivopixant; S-600918; S 600918; S600918

Çareserî:Di DMSO de çareser dibe

Embarkirinî:Ziwa, tarî û di 0 - 4 C de ji bo demek kurt (roj heta hefte) an -20 C ji bo demek dirêj (mehan heta salan)

Terîf:

Sivopixant, ku wekî S-600918 jî tê zanîn, dijberek receptorê P2X3 bijartî ye (P2X3 IC50, 4.2 nM; P2X2 / 3 IC50, 1100 nM). Sivopixant bandorek analjezîk a bihêz di modela girêbirîna nerva sciatic ya qismî ya mişk de (modela Seltzer) a allodynia (ED50, 0.4 mg / kg) nîşan da.

Armanc: dijberê receptorê P2X3 bijartî