Resmetirom

Aha kemịkalụ:

Resmetirom

Koodu Ọchịchọ:

N#CC1=NN(C2=CC(Cl)=C(OC(C=C3C(C)C)=NNC3=O)C(Cl)=C2)C(NC1=O)=O

Koodu InChi:

InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25- 17 (28) 21-16 (27) 12 (6-20) 24-25/h3-5,7H,1-2H3, (H,23,26) (H,21,27,28)

Igodo InChi:

FDBYIYFVSAHJLY-UHFFFAOYSA-N

Okwu:

MGL-3196; MGL 3196; VIA 3196; VIA-3196; Resmetirom

Solubility:Soluble na DMSO, ọ bụghị na mmiri

Nchekwa:0 - 4 C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 C maka ogologo oge (ọnwa)

Nkọwa:

Resmetirom, nke a makwaara dị ka MGL-3196, bụ onye nwere ike na nke ukwuu nhọrọ thyroid hormone receptor β agonist n'ime ule ụlọ ọgwụ maka ọgwụgwọ dyslipidemia. Mmetụta bara uru nke hormone thyroid (TH) na ọkwa lipid bụ isi n'ihi ihe ọ na-eme na thyroid hormone receptor β (THR-β) na imeju, ebe mmetụta ọjọọ, gụnyere mmetụta obi obi, na-edozi site na thyroid hormone receptor α (THR). -a).

Ebumnuche: THR-β