Quarfloxin

Aha kemịkalụ:

5-fluoro-N- (2- ((S) -1-methylpyrrolidin-2-yl) ethyl -3-oxo-6- ((R) -3- (pyrazin-2-yl) pyrrolidin-1-yl -3H-benzo [b] pyrido [3,2,1-kl] phenoxazine-2-carboxamide

Koodu Ọchịchọ:

FC1=C(N2CC[C@@H](C3=CN=CC=N3)C2)C(OC4=C5C=C6C(C=CC=C6)=C4)=C(N5C=C(C(NCC) C@H]7N(C)CCC7)=O)C8=O)C8=C1

Koodu InChi:

InChi=1S/C35H33FN6O3/c1-40-13-4-7-24(40)8-10-39-35(44)26-20-42-29-15-21-5-2-3-6- 22 (21) 16-30 (29) 45-34-31 (42)25 (33 (26) 43) 17-27 (36) 32 (34) 41-14-9-23 (19-41) 28- 18-37-11-12-38-28/h2-3,5-6,11-12,15-18,20,23-24H,4,7-10,13-14,19H2,1H3,(H ,39,44)/t23-,24+/m1/s1

Igodo InChi:

WOQIDNWTQOYDLF-RPWUZVMVSA-N

Okwu:

CX 3543; CX-3543; CX 3543; Quarfloxacin

Solubility: 

Nchekwa: 

Nkọwa:

Quarfloxin, nke a makwaara dị ka Quarfloxacin na CX-3543, bụ ihe nrụpụta fluoroquinolone nwere ọrụ antineoplastic. Quarfloxin na-akpaghasị mmekọrịta dị n'etiti protein nucleolin na usoro DNA nke G-quadruplex na DNA ribosomal DNA (rDNA), mmekọrịta dị oke mkpa maka rRNA biogenesis nke na-ejupụta na mkpụrụ ndụ cancer; nkwụsị nke DNA G-quadruplex a: mmekọrịta protein na rRNA biogenesis na-adịghị mma nwere ike ime ka mgbochi nke ribosome synthesis na tumor cell apoptosis.

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