| nwamba # | Aha ngwaahịa | Nkọwa |
| CPD100608 | ASK1-Inhibitor-10 | ASK1 Inhibitor 10 bụ ihe mgbochi ọnụ nke nwere ike ime ihe mgbochi apoptosis na-achịkwa kinase 1 (ASK1). Ọ bụ nhọrọ maka ASK1 karịa ASK2 yana MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, na B-RAF. Ọ na-egbochi mmụba nke streptozotocin na-ebute na JNK na p38 phosphorylation na mkpụrụ ndụ β pancreatic nke INS-1 n'ụzọ dabere na ntinye uche. |
| CPD100607 | K811 | K811 bụ ihe mgbochi ASK1 akọwapụtara nke na-agbatị ndụ n'ụdị òké nke sclerosis nke amyotrophic. K811 gbochiri nke ọma mmụba cell n'ahịrị sel nwere okwu ASK1 dị elu yana n'ime sel HER2-overexpressing GC. Ọgwụgwọ na K811 belatara nha etuto xenograft site na iwetu akara nrịbawanye. |
| CPD100606 | K812 | K812 bụ ihe mgbochi ASK1 akọwapụtara ka ọ ga-adị ogologo ndụ n'ụdị òké nke sclerosis nke amyotrophic. |
| CPD100605 | MSC-2032964A | MSC 2032964A bụ onye nwere ike na nhọrọ ASK1 inhibitor (IC50 = 93 nM). Ọ na-egbochi LPS na-ebute ASK1 na p38 phosphorylation na astrocytes òké omenala ma na-egbochi neuroinflammation na ụdị EAE òké. MSC 2032964A bụ ihe dị ndụ n'ọnụ yana ihe na-abanye n'ụbụrụ. |
| CPD100604 | Selonsertib | Selonsertib, nke a makwaara dị ka GS-4997, bụ onye na-emechi ọnụ nke ihe mgbochi nke apoptosis na-achịkwa kinase 1 (ASK1), nke nwere ike igbochi mkpali, antineoplastic na mgbochi fibrotic. GS-4997 lekwasịrị anya ma jikọta na ngalaba catalytic kinase nke ASK1 n'ụzọ asọmpi ATP, si otú a gbochie phosphorylation na ịgbalite ya. GS-4997 na-egbochi mmepụta nke cytokines na-egbuke egbuke, na-edozi okwu nke mkpụrụ ndụ ihe nketa na-etinye aka na fibrosis, na-egbochi apoptosis gabigara ókè ma gbochie mgbasawanye cellular. |
