| nwamba # | Aha ngwaahịa | Nkọwa |
| CPD100603 | MDK36122 | MDK36122, makwaara dị ka H-PGDS Inhibitor I, bụ onye na-egbochi Prostaglandin D Synthase (ụdị hematopoietic). MDK36122 enweghị aha koodu, ma nwee CAS#1033836-12-2. Ejiri ọnụọgụ 5 ikpeazụ maka aha maka nzikọrịta ozi dị mfe. MDK36122 na-ahọrọ egbochi HPGDS (IC50s = 0.7 na 32 nM na enzyme na nyocha cellular, n'otu n'otu) na obere ọrụ megide enzymes mmadụ metụtara L-PGDS, mPGES, COX-1, COX-2, na 5-LOX. |
| CPD100602 | Tepoxalin | Tepoxalin, nke a makwaara dị ka ORF-20485; RWJ-20485; bụ 5-lipoxygenase inhibitor nwere ike maka ọgwụgwọ ụkwara ume ọkụ, osteoarthritis (OA). Tepoxalin nwere ọrụ inhibitory vivo megide COX-1, COX-2, na 5-LOX na nkịta na usoro ọgwụgwọ a kwadoro ugbu a. Tepoxalin na-akwalite ọrụ nke antioxidant, pyrrolidine dithiocarbamate, na attenuating tumor necrosis factor alpha-induced apoptosis na sel WEHI 164. |
| CPD100601 | Tenidap | Tenidap, nke a makwaara dị ka CP-66248, bụ onye na-emechi COX / 5-LOX na onye nyocha ọgwụ mgbochi cytokine-modulating nke Pfizer na-emepe emepe dị ka ọgwụgwọ na-ekwe nkwa maka ọrịa ogbu na nkwonkwo, ma Pfizer kwụsịrị mmepe mgbe a jụrụ nkwado ahịa ahịa. site na FDA na 1996 n'ihi imeju na akụrụ na-egbu egbu, nke a na-ekwu na metabolites nke ọgwụ na-eme ka ọkpụkpụ thiophene kpatara mmebi oxidative. |
| CPD100600 | PF-4191834 | PF-4191834 bụ akwụkwọ akụkọ, ike na nhọrọ na-abụghị redox 5-lipoxygenase inhibitor dị irè na mbufụt na mgbu. PF-4191834 na-egosipụta ike dị mma na nyocha enzyme- na nyocha nke cell, yana n'ụdị oke oke mbufụt. Nsonaazụ nyocha nke Enzyme na-egosi na PF-4191834 bụ ihe mgbochi 5-LOX nwere ike, yana IC (50) = 229 +/- 20 nM. Ọzọkwa, o gosipụtara ihe dịka 300-fold selectivity maka 5-LOX n'elu 12-LOX na 15-LOX ma na-egosi na ọ dịghị ọrụ na cyclooxygenase enzymes. Na mgbakwunye, PF-4191834 na-egbochi 5-LOX na sel ọbara mmadụ, yana IC (80) = 370 +/- 20 nM. |
| CPD100599 | MK-886 | MK-886, makwaara dị ka L 663536, bụ onye na-emegide leukotriene. Ọ nwere ike ime nke a site na igbochi protein 5-lipoxygenase activating (FLAP), si otú a na-egbochi 5-lipoxygenase (5-LOX), ma nwee ike inye aka n'ịgwọ atherosclerosis. MK-886 na-egbochi ọrụ cyclooxygenase-1 ma na-egbochi nchịkọta platelet. MK-886 na-ebute mgbanwe na okirikiri cell ma na-abawanye apoptosis mgbe ọgwụgwọ photodynamic na hypericin gasịrị. MK-886 na-akwalite etuto necrosis factor-alpha-induced iche na apoptosis. |
| CPD100598 | L-691816 | L 691816 bụ ihe mgbochi siri ike nke mmeghachi omume 5-LO ma in vitro na n'ọtụtụ ụdị vivo. |
| CPD100597 | CMI-977 | CMI-977, nke a makwaara dị ka LPD-977 na MLN-977, bụ ihe mgbochi 5-lipoxygenase siri ike nke na-etinye aka na mmepụta nke leukotrienes ma na-emepụta ugbu a maka ọgwụgwọ ụkwara ume ọkụ na-adịghị ala ala. CMI-977 na-egbochi ụzọ mbufụt nke 5-lipoxygenase (5-LO) iji gbochie ọgbọ nke leukotrienes, nke na-arụ ọrụ dị mkpa n'ịkpalite ụkwara ume ọkụ. |
| CPD100596 | CJ-13610 | CJ-13610 bụ onye na-egbochi ọnụ nke 5-lipoxygenase (5-LO). CJ-13610 na-egbochi biosynthesis nke leukotriene B4 ma na-achịkwa okwu IL-6 mRNA na macrophages. Ọ dị irè na ụdị mgbu mgbu. |
| CPD100595 | BRP-7 | BRP-7 bụ onye na-egbochi protein 5-LO (FLAP). |
