Ingliforib

Aha kemịkalụ:

5-chloro-N-((2S,3R)-4-((3S,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-hydroxy-4-oxo-1-phenylbutan-2-yl) 1H-indole-2-carboxamide

Koodu Ọchịchọ:

O[C@H](C1)[C@@H](O)CN1C([C@H](O)[C@H](CC2=CC=CC=C2)NC(C3=CC4=C( N3)C=CC(Cl)=C4)=O)=O

Koodu InChi:

InChI=1S/C23H24ClN3O5/c24-15-6-7-16-14(9-15)10-18(25-16)22(31)26-17(8-13-4-2-1-3- 5-13)21 (30)23 (3 2)27-11-19(28)20(29)12-27/h1-7,9-10,17,19-21,25,28-30H,8,11-12H2,(H,26,31 )/t17-,19-,20+,21+/m0/s1

Igodo InChi:

GVDRRZOORHCTAN-MJUUVYJYSA-N

Okwu:

Ingliforib; CP-296; CP-368; CP-368,296; CP296; CP 296; CP-368296; CP368296; CP 368296

Solubility:DMSO

Nchekwa: 

Nkọwa:

Ingliforib, nke a makwaara dị ka CP-368296, bụ ihe mgbochi glycogen phosphorylase ọhụrụ. Ingliforib nwere mmetụta antihyperglycemic na cardioprotective. Ingliforib na-egbochi glycogen phosphorylase, enzyme na-ebelata ọnụego na glycogenolysis, si otú a na-egbochi mwepụta nke glucose-1 phosphate na molekul glycogen na imeju. Onye ọrụ a na-egbochikwa glycogen phosphorylase na akwara obi ma nwee ike ichebe obi pụọ na mmerụ ahụ ischemic myocardial site na ichekwa ọdịnaya glycogen na imeziwanye njikọ glycolytic-oxidative.

Ebumnuche: glycogen phosphorylase