BMS-986195

Aha kemịkalụ:

(S) -4- (3- (ma-2-ynamido) piperidin-1-yl) -5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide

Koodu Ọchịchọ:

FC1=C(N2CCC[C@H](NC(C#CC)=O)C2)C3=C(NC(C)=C3C)C(C(N)=O)=C1

Koodu InChi:

InChi=1S/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18 -17(19)11(2)12(3)23-18/h9,13,23H,5,7-8,10H2,1-3H3,(H2,22,27)(H,24,26)/ t13-/m0/s1

Igodo InChi:

VJPPLCNBDLZIFG-ZDUSSCGKSA-N

Okwu:

BMS-986195, BMS 986195, BMS986195, 1912445-55-6

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

BMS-986195 bụ onye nwere ike, covalent, onye na-egbochi tyrosine kinase nke Bruton (BTK), onye otu ezinụlọ Tec nke tyrosine kinases na-adịghị anabata ihe dị mkpa na njirimara B-cell na-adabere na antigen. BMS-986195 karịrị 5000-fold ahọpụtara maka BTK karịa kinase niile na-abụghị ezinụlọ Tec, na nhọrọ nhọrọ sitere na 9- ruo 1010-fold n'ime ezinụlọ Tec. BMS-986195 na-arụ ọrụ BTK n'ime ọbara mmadụ dum na ngwa ngwa nke inactivation (3.5 × 10-4 nM-1 · min-1) ma gbochie mmepụta interleukin-6 antigen-based antigen, okwu CD86 na mmụba na mkpụrụ ndụ B (IC50).<1 nM) na-enweghị mmetụta na usoro antigen na-adabere na otu sel.

Ebumnuche: BTK