BI-2852

Aha kemịkalụ:

(S) -5-hydroxy-3- (2- (((1- ((1-methyl-1H-imidazole-4-yl)methyl)) -1H-indol-6-yl) methyl) amino) methyl) -1H-indol-3-yl) isoindolin-1-otu

Koodu Ọchịchọ:

OC(C=C1)=CC([C@@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62) N7)=C1C7=O

Koodu InChi:

InChi=1S/C31H28N6O2/c1-36-16-21(33-18-36)17-37-11-10-20-7-6-19(12-28(20)37)14-32-15- 27-29 (24-4-2-3-5-26 (2 4)34-27)30-25-13-22(38)8-9-23(25)31(39)35-30/h2-13,16,18,30,32,34,38H,14- 15,17H2,1H3,(H,35,39)/t30-/m0/s1

Igodo InChi:

JYEQLXOWWLNVDX-PMERELPUSA-N

Okwu:

Solubility: 

Nchekwa: 

Nkọwa:

BI-2852 bụ ihe mgbochi KRAS siri ike nke na-ejikọta na nanomolar affinity na akpa, nke a na-aghọta na ọ bụ "enweghị ike ịgbagha," n'etiti mgba ọkụ I na II na RAS. BI-2852 dị iche n'ụdị usoro na ihe mgbochi KRASG12C n'ihi na ọ na-ejikọta na akpa dị iche iche dị na ụdị KRAS na-arụ ọrụ na nke anaghị arụ ọrụ. BI-2852 na-egbochi GEF, GAP, na mmekọrịta mmetụta ya na KRAS, na-eduga na mgbochi nke akara ngosi ala na mmetụta antiproliferative na sel mutant KRAS.

Ebumnuche: KRAS