TIAB SA 8186

Lub npe tshuaj:

(R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

SMILES Code:

O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C=C(C(O3)N4CCOCC4)) =O)=C1

InChi Code:

InChI = 1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3 9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14 -/m1/s1

InChi Key:

LMJFJIDLEAWOQJ-CQSZACIVSA-N

Lo lus tseem ceeb:

AZD 8186, AZD-8186, AZD 8186, 1627494-13-6

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

Nqe lus piav qhia:

AZD8186 yog thiab inhibitor ntawm beta isoform ntawm phosphoinositide-3 kinase (PI3K), uas muaj peev xwm ua haujlwm antineoplastic. Raws li kev tswj hwm, PI3Kbeta inhibitor AZD8186 xaiv inhibits kev ua haujlwm ntawm PI3Kbeta hauv PI3K / Akt / mTOR teeb liab txoj hauv kev, uas yuav ua rau txo qis ntawm cov qog cell proliferation. Nws kuj induces cell tuag nyob rau hauv PI3K-expressing cancer hlwb. Los ntawm tshwj xeeb tsom rau chav kawm I PI3K beta, tus neeg sawv cev no yuav ua tau zoo dua thiab tsis muaj tshuaj lom ntau dua li PI3K inhibitors. PI3K-mediated signaling feem ntau dysregulated nyob rau hauv cov qog nqaij hlav cancer thiab pab txhawb cov qog cell loj hlob, ciaj sia taus, thiab qog tsis kam mus rau ntau yam ntawm cov tshuaj antineoplastic. AZD8186 tam sim no nyob rau theem I kev sim tshuaj.

Hom phiaj: PI3K