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Sitagliptin

Sitagliptin
  • Lub npe:Sitagliptin
  • Catalog No.:TSI 0100
  • CAS Nr:.654671-77-9 (Sitagliptin Phosphate Monohydrate); 654671-78-0 (Sitagliptin Phosphate ); 486460-32-6 (dawb puag)
  • Molecular Luj:407.31 Nws
  • Tshuaj Formula:C16H15F6N5O
  • Rau kev tshawb fawb tshawb fawb nkaus xwb, tsis yog rau cov neeg mob.

    Product Detail

    Khoom cim npe

    Pob Loj Muaj Nqe (USD)

    Lub npe tshuaj:

    Sitagliptin (INN; yav dhau los pom tias yog MK-0431 thiab muag hauv lub npe lag luam Januvia) yog ib qho tshuaj tiv thaiv kab mob hauv qhov ncauj (cov tshuaj tiv thaiv kab mob ntshav qab zib) ntawm dipeptidyl peptidase-4 (DPP-4) inhibitor class.

    SMILES Code:

    O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O )(O)O[H]O[H]

    InChi Code:

    InChI = 1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27- 13(7- 26) 24-25-15(27)16(20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;(H3,1, 2,3,4);1H2/t9-;/m1../s1

    InChi Key:

    GQPYTJVDPQTBQC-KLQYNRQASA-N

    Lo lus tseem ceeb:

    Sitagliptin, Sitagliptin phosphate, Januvia, Glactiv, ONO-5435, MK-0431, L-000224715, 654671-77-9,654671-78-0, 486460-32-6

    Solubility:Soluble hauv DMSO

    Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

    Nqe lus piav qhia:

    Sitagliptin (INN; yav dhau los pom tias yog MK-0431 thiab muag hauv lub npe lag luam Januvia) yog ib qho tshuaj tiv thaiv kab mob hauv qhov ncauj (cov tshuaj tiv thaiv kab mob ntshav qab zib) ntawm dipeptidyl peptidase-4 (DPP-4) inhibitor class. Nws tau tsim thiab ua lag luam los ntawm Merck & Co. Cov tshuaj enzyme-inhibiting no yog siv ib leeg lossis ua ke nrog lwm cov tshuaj tiv thaiv qhov ncauj (xws li metformin lossis thiazolidinedione) rau kev kho mob ntshav qab zib mellitus hom 2. Cov txiaj ntsig ntawm cov tshuaj no yog nws cov kev cuam tshuam qis dua (piv txwv li, hypoglycemia tsawg dua, qhov hnyav nce) hauv kev tswj cov ntshav qabzib cov txiaj ntsig. Exenatide (Byteta) kuj ua haujlwm los ntawm nws cov nyhuv ntawm incretin system.

    Hom phiaj: DPP-4


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