Linagliptin

Lub npe tshuaj:

8-[(3R)-3-aminopiperidin-1-yl]-7-(but-2-yn-1-yl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3 ,7-dihydro-1H-purine-2,6-dione

SMILES Code:

O=C(N1CC2=NC(C)=C3C=CC=CC3=N2)N(C)C4=C(N(CC#CC)C(N5C[C@H](N)CCC5)=N4)C1 =O

InChi Code:

InChI = 1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35) 33(23(21 34) 15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H, 8-9,12-15,26H2 ,1-3H3/t17-/m1/s1

InChi Key:

LTXREWYXXSTFRX-QGZVFWFLSA-N

Lo lus tseem ceeb:

Linagliptin, BI-1356, BI 1356, BI1356, 668270-12-0

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

Linagliptin, tseem hu ua BI-1356, yog DPP-4 inhibitor tsim los ntawm Boehringer Ingelheim rau kev kho mob ntshav qab zib hom II. Linagliptin (ib hnub ib zaug) tau pom zoo los ntawm US FDA ntawm 2 Tsib Hlis 2011 rau kev kho mob ntshav qab zib hom II. Nws tab tom ua lag luam los ntawm Boehringer Ingelheim thiab Lilly.

Hom phiaj: DPP-4