PRT-060318; PRT318; P142–76

Lub npe tshuaj:

2-(((1R,2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide

SMILES Code:

O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N

InChi Code:

InChI = 1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8- 3-2-7 -14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22,23,24)/ t14-,15+/m0/s1

InChi Key:

NZNTWOVDIXCHHS-LSDHHAIUSA-N

Lo lus tseem ceeb:

PRT-060318, PRT-318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

Nqe lus piav qhia:

PRT060318 yog ib qho muaj zog thiab xaiv inhibitor ntawm tus po tyrosine kinase (Syk; IC50 = 4 nM). 270 ua. PRT060318 inhibits convulxin-induced aggregation ntawm tib neeg platelet-nplua nuj plasma (IC50 = 2.5 μM) nyob rau hauv vitro thiab tiv thaiv thrombosis nyob rau hauv ib tug transgenic nas qauv ntawm heparin-induced thrombocytopenia. Nws induces chronic lymphocytic leukemia (CLL) B cell apoptosis thiab inhibits lub secretion ntawm chemokines CCL3, CCL4, thiab CXCL13.3 PRT060318 kuj inhibits CLL B cell chemotaxis thiab pseudoemperipolesis.

Hom phiaj: Syk