86-21-64556180 ib

PRT-060318; PRT318; P142–76

PRT-060318; PRT318; P142–76
  • Lub npe:PRT-060318; PRT318; P142–76
  • Catalog No.:TIAB SA 3529
  • CAS Nr:.1194961-19-7
  • Molecular Luj:340.4 ib
  • Tshuaj Formula:C18H24N6O
  • Rau kev tshawb fawb tshawb fawb nkaus xwb, tsis yog rau cov neeg mob.

    Product Detail

    Khoom cim npe

    Pob Loj Muaj Nqe (USD)
    500 mg Hauv Tshuag 900
    1g Hauv Tshuag 1350
    Ntau qhov ntau thiab tsawg Tau txais Quotes Tau txais Quotes

    Lub npe tshuaj:

    2-(((1R,2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide

    SMILES Code:

    O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N

    InChi Code:

    InChI = 1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8- 3-2-7 -14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22,23,24)/ t14-,15+/m0/s1

    InChi Key:

    NZNTWOVDIXCHHS-LSDHHAIUSA-N

    Lo lus tseem ceeb:

    PRT-060318, PRT-318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7

    Solubility:Soluble hauv DMSO

    Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

    Nqe lus piav qhia:

    PRT060318 yog ib qho muaj zog thiab xaiv inhibitor ntawm tus po tyrosine kinase (Syk; IC50 = 4 nM). 270 ua. PRT060318 inhibits convulxin-induced aggregation ntawm tib neeg platelet-nplua nuj plasma (IC50 = 2.5 μM) nyob rau hauv vitro thiab tiv thaiv thrombosis nyob rau hauv ib tug transgenic nas qauv ntawm heparin-induced thrombocytopenia. Nws induces chronic lymphocytic leukemia (CLL) B cell apoptosis thiab inhibits lub secretion ntawm chemokines CCL3, CCL4, thiab CXCL13.3 PRT060318 kuj inhibits CLL B cell chemotaxis thiab pseudoemperipolesis.

    Hom phiaj: Syk


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