BAY 61-3606 2 HCl

Lub npe tshuaj:

2-[[7-(3,4-Dimethoxyphenyl) imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide dihydrochloride

SMILES Code:

O=C(N)C1=C(NC2=NC(C3=CC=C(OC)C(OC)=C3)=CC4=NC=CN24)N=CC=C1.[H]Cl.[H] Cl

InChi Code:

InChI = 1S/C20H18N6O3.2ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20 (24-14) 25-19-13(18(21)27)4-3-7-23-19;;/h3-11H,1-2H3,(H2,21,27)H,23,24 25); 2 * 1H

InChi Key:

SPMFEULFGGPQLN-UHFFFAOYSA-N

Lo lus tseem ceeb:

PEB 61-3606, 648903-57-5, BAY 613606, BAY-613606, BAY-61-3606

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

Nqe lus piav qhia:

BAY 61-3606 yog lub zog (Ki = 7.5 nM) thiab xaiv inhibitor ntawm Syk kinase. BAY 61-3606 inhibited tsis tsuas degranulation (IC50 qhov tseem ceeb ntawm 5 thiab 46 nM) tab sis kuj lipid mediator thiab cytokine synthesis hauv mast hlwb. BAY 61-3606 tau txais txiaj ntsig zoo hauv basophils tau los ntawm cov tib neeg noj qab haus huv (IC50 = 10 nM) thiab zoo li tsawg kawg li muaj zog hauv basophils tau los ntawm atopic (high serum IgE) cov ntsiab lus (IC50 = 8.1 nM). B cell receptor activation thiab receptors rau Fc feem ntawm IgG signaling nyob rau hauv eosinophils thiab monocytes kuj muaj zog suppressed los ntawm BAY 61-3606.

Hom phiaj: Syk