TIAB SA 4547

Lub npe tshuaj:

N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide

SMILES Code:

O=C(NC1=NNC(CCC2=CC(OC)=CC(OC)=C2)=C1)C3=CC=C(N4C[C@H](C)N[C@H](C)C4 C = C3

InChi Code:

InChI = 1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21( 29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8, 15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+

InChi Key:

VRQMAABPASPXMW-HDICACEKSA-N

Lo lus tseem ceeb:

AZD 4547, AZD-4547, AZD 4547, 1035270-39-3

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

Nqe lus piav qhia:

AZD 4547 yog ib qho kev xaiv inhibitor ntawm fibroblast kev loj hlob zoo receptor (FGFR) tyrosine kinase nrog IC50 qhov tseem ceeb ntawm 0.2, 2.5, thiab 1.8 nM rau FGFR1, 2, thiab 3, feem.

Hom phiaj: FGFR