TAS-120

Lub npe tshuaj:

1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl] -2-propen-1-ib

SMILES Code:

C=CC(N1C[C@@H](N2N=C(C#CC3=CC(OC)=CC(OC)=C3)C4=C(N)N=CN=C42)CC1)=O

InChi Code:

InChI = 1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28) 6-5 -14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23, 24,25)/t15-/m0/s1

InChi Key:

KEIPNCCJPRMIAX-HNNXBMFYSA-N

Lo lus tseem ceeb:

TAS-120

Solubility: 

Cia: 

Nqe lus piav qhia:

TAS-120 yog ib qho kev hais lus bioavailable inhibitor ntawm fibroblast kev loj hlob receptor (FGFR) uas muaj peev xwm ua haujlwm antineoplastic. FGFR inhibitor TAS-120 xaiv thiab irreversibly khi rau thiab inhibits FGFR, uas yuav ua rau inhibition ntawm ob qho tib si FGFR-mediated signal transduction pathway thiab qog cell proliferation, thiab nce cell tuag nyob rau hauv FGFR-overexpressing qog hlwb. FGFR yog ib qho receptor tyrosine kinase tseem ceeb rau qog cell proliferation, sib txawv thiab ciaj sia taus thiab nws cov lus qhia yog upregulated nyob rau hauv ntau hom qog cell.

Hom phiaj: FGFR