PEB-9931

Lub npe tshuaj:

N-(2-(((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide

SMILES Code:

C=CC(NC1=CC=CC(C)=C1NC2=NC=C3C=C(C4=C(Cl)C(Cl)C(OC)=CC(OC)=C4Cl)C=CC3=N2)=O

InChi Code:

InChI = 1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10- 17(16)31-26(22)-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33) ) (H, 29, 31, 32) ib.

InChi Key:

TXEBNKKOLVBTFK-UHFFFAOYSA-N

Lo lus tseem ceeb:

BLU-9931, BLU9931, BLU 9931, 1538604-68-0

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

Hauv MDA-MB-453 hlwb, BLU9931 muaj zog inhibits phosphorylation ntawm FGFR4 signaling pathway. BLU9931 inhibits kev loj hlob ntawm HCC kab ntawm tes uas qhia txog qhov tsis zoo ntawm FGFR4 teeb liab, xws li Hep 3B, HUH-7, thiab JHH-7 cell kab, nrog EC50 ntawm<1 μM. BLU9931 tseem inhibits kev loj hlob ntawm PDX-derived cell kab nrog rau qhov tsis zoo FGFR4 signaling pathway[1]. BLU9931 induces qog shrinkage nyob rau hauv hepatocellular carcinoma qauv uas qhia txog ib tug ua hauj lwm ligand / receptor complex muaj xws li FGF19 / FGFR4 / KLB thiab ntxiv rau cov npe loj hlob ntawm cov tshuaj tiv thaiv FGFR4 [2].

Hom phiaj: FGFR4