AMG-510

Lub npe tshuaj:

4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl pyrido[2,3-d]pyrimidin-2(1H)-ib

SMILES Code:

O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C))C=CN=C3C(C)C)C4=C2C=C(F)C (C5=C(O)C=CC=C5F)=N4)=O)CC1

InChi Code:

InChI = 1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8- 7-9-22(24)39-34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6- 11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1

InChi Key:

NXQKSXLFSAEQCZ-SFHVURJKSA-N

Lo lus tseem ceeb:

AMG-510; AMG 510; AMG510

Solubility: 

Cia: 

Nqe lus piav qhia:

AMG-510 yog KRAS G12C covalent inhibitor muaj zog. AMG-510 xaiv lub hom phiaj ntawm KRAS p.G12C mutant, ntawm DNA, RNA lossis qib protein, thiab tiv thaiv, los ntawm qhov tseem tsis tau piav qhia, kev qhia ntawm thiab / lossis qog cell signaling los ntawm KRAS p.G12C mutant. Qhov no tuaj yeem cuam tshuam kev loj hlob hauv KRAS p.G12C-expressing qog hlwb

Hom phiaj: KRAS