PEB 226

Lub npe tshuaj:

N-(furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine

SMILES Code:

O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O

InChi Code:

InChI = 1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-11-20-21-16(15)22) 18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19)

InChi Key:

DYIRSNMPIZZNBK-UHFFFAOYSA-N

Lo lus tseem ceeb:

PEB 226, EED-226, EED 226, 2083627-02-3

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

EED226 yog lub zog muaj zog, muaj txiaj ntsig zoo thiab xaiv inhibitor ntawm EZH2 thiab EZH1 tshuaj xyuas tawm tsam ntau yam ntawm epigenetic thiab non-epigenetic lub hom phiaj. Nws muaj peev xwm txo qis H3K27Me3 cim thoob ntiaj teb hauv cov hlwb thiab ua kom pom kev xaiv cov tshuaj tua kab mob hauv cov hlwb uas muaj kev hloov pauv ntawm Y641N heterozygous. EED226 muaj qhov nruab nrab permeability raws li qhov ntsuas hauv Caco-2 hlwb ntawm A→ B = 3.0x10-6 cm / s, nrog rau qhov sib piv ntawm 7.6 [1].

Hom phiaj: EED226