SIB-3406

Lub npe tshuaj:

N-((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-((((S)-tetrahydrofuran-3-yl)oxy)quinazolin- 4-am

SMILES Code:

C[C@H](C1=CC(N)=CC(C(F)(F)F)=C1)NC2=C3C(C=C(OC)C(O[C@H]4CCOC4)=C3 ) = NC(C) = N2

InChi Code:

InChI = 1S/C23H25F3N4O3/c1-12(14-6-15(23(24,25)26)8-16(27)7-14)28-22-18-9-21(33-17-4- 5-32-11- 17) 20(31-3)10-19(18)29-13(2)30-22/h6-10,12,17H,4-5,11,27H2,1-3H3,(H,28,29) ,30)/t12-,17+/m1/s1

InChi Key:

XVFDNRYZXDHTHT-PXAZEXFGSA-N

Lo lus tseem ceeb:

IB-3406; IB 3406; TIAB SA 3406

Solubility: 

Cia: 

Nqe lus piav qhia:

BI-3406 yog Muaj Peev Xwm & Xaiv SOS1::KRAS Inhibitor (IC50 = 5 nM), uas qhib txoj hauv kev tshiab rau kev kho KRAS-Driven Tumours. BI 3406 xaiv khi rau SOS1 thiab thaiv kev cuam tshuam nrog KRAS, tsis hais txog KRAS kev hloov pauv. BI 3406 ua rau RAS GTP thiab pERK txo qis thiab inhibits cell loj hlob ntawm KRAS mutated cell kab, nqa feem ntau ntawm KRAS kev hloov pauv (ie G12D, G12V, G13D thiab lwm yam). BI 3406, thaum muab qhov ncauj rau cov qog nqaij hlav nas, ua rau cov kab mob qog noj ntshav zoo li qub uas tuaj yeem hloov mus rau hauv kev rov ua dua thaum ua ke nrog MEK1 inhibition.

Hom phiaj: SOS1