SOS 1

CAT #	Khoom npe	Kev piav qhia
PIB 10000	SIB-3406	BI-3406 yog Muaj Peev Xwm & Xaiv SOS1::KRAS Inhibitor (IC50 = 5 nM), uas qhib txoj hauv kev tshiab rau kev kho KRAS-Driven Tumours. BI 3406 xaiv khi rau SOS1 thiab thaiv kev cuam tshuam nrog KRAS, tsis hais txog KRAS kev hloov pauv. BI 3406 ua rau RAS GTP thiab pERK txo qis thiab inhibits cell loj hlob ntawm KRAS mutated cell kab, nqa feem ntau ntawm KRAS kev hloov pauv (ie G12D, G12V, G13D thiab lwm yam). BI 3406, thaum muab qhov ncauj rau cov qog nqaij hlav nas, ua rau cov kab mob qog noj ntshav zoo li qub uas tuaj yeem hloov mus rau hauv kev rov ua dua thaum ua ke nrog MEK1 inhibition.
PEB 2807	PEB-293	BAY-293 yog ib qho muaj zog SOS1 inhibitor uas thaiv RAS ua kom muaj kev cuam tshuam ntawm RAS-SOS1 kev cuam tshuam. BAY-293) xaiv inhibits KRAS-SOS1 kev cuam tshuam nrog IC50 ntawm 21 nM thiab yog ib qho tseem ceeb tshuaj soj ntsuam rau kev tshawb nrhiav yav tom ntej.