BMS-986165

Lub npe tshuaj:

6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3 - carboxamide

SMILES Code:

O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[ 2 H]

InChi Code:

InChI = 1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4- 5-12(17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)( H2,23,24,25,29)/i1D3

InChi Key:

BZZKEPGENYLQSC-FIBGUPNXSA-N

Lo lus tseem ceeb:

1609392-27-9; CAS: 1609392-27-9; CAS: 1609392-27-9; BMS-986165; BMS 986165; BMS986165; Deucravacitinib

Solubility:Soluble hauv DMSO

Cia:Qhuav, tsaus thiab ntawm 0 - 4 C rau lub sijhawm luv (hnub mus rau lub lis piam) lossis -20 C rau lub sijhawm ntev (hli mus rau xyoo).

Nqe lus piav qhia:

BMS-986165 yog lub zog muaj zog thiab xaiv Allosteric Inhibitor ntawm TYK2. BMS-986165 Blocks Il-12, IL-23 thiab hom I Interferon Signaling thiab muab kev ua haujlwm zoo hauv cov qauv ua ntej ntawm Kab Mob plab hnyuv. MS-986165 muaj zog khi rau Tyk2 pseudokinase domain (Ki = 0.02 nM), thiab muaj kev xaiv heev tiv thaiv lub vaj huam sib luag ntawm 265 kinases thiab pseudokinases. Cov tshuaj muaj zog inhibited IL-23-, IL-12-, thiab Hom I interferon-tsav cellular signaling thiab transcriptional teb (IC50 ntau 2-14 nM).

Hom phiaj: TYK2