TSI-045

Lub npe tshuaj:

2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide

SMILES Code:

O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N3CC4=C(C=CC=C4)C3=O

InChi Code:

InChI=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8-27-19)23-10-11- 3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)

InChi Key:

YTUFHOKUFOQRDF-UHFFFAOYSA-N

Lo lus tseem ceeb:

EAI-045, EAI045, EAI 045, 1942114-09-1

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

Nqe lus piav qhia:

EAI045 yog lub zog thiab xaiv EGFR inhbitor. EAI045 lub hom phiaj xaiv cov tshuaj tiv thaiv EGFR mutants tab sis cia cov tsiaj qus receptors. EAI045 inhibits L858R / T790M-mutant EGFR nrog qis-nanomolar potency hauv biochemical ntsuam xyuas.

Hom phiaj: EGFR