Quizartinib; AC-010220; AC-220

Lub npe tshuaj:

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl ]phenyl}urea

SMILES Code:

O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5))=CC=C34)=N2)C=C1)NC6=NOC(C)(C)C)=C6

InChi Code:

InChI = 1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22- 18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4- 9,16-18H, 10-15H2,1-3H3, (H2,30,32,33,36)

InChi Key:

CVWXJKQAOSCOAB-UHFFFAOYSA-N

Lo lus tseem ceeb:

Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

Nqe lus piav qhia:

Quizartinib yog ib qho inhibitor ntawm FMS-txog tyrosine kinase 3 (FLT3; Kd = 1.6 nM) thiab ua kom pom kev xaiv siab rau FLT3 thaum kuaj tawm tsam ntawm 227 kinases ntxiv. Nws inhibits qhov kev loj hlob ntawm tib neeg leukemia cell kab MV4-11, uas harbors ib homozygous FLT3-ITD kev hloov, nrog rau IC50 tus nqi ntawm 0.56 nM.1 Ntawm 1 mg / kg / hnub, quizartinib tau pom tias kom muaj sia nyob ntev hauv nas. qauv ntawm FLT3-ITD mob myeloid leukemia thiab tshem tawm cov qog hauv FLT3-dependent nas xenograft qauv ntawm 10 mg / kg.

Hom phiaj: FLT3