86-21-64556180 ib

Quizartinib; AC-010220; AC-220

Quizartinib; AC-010220; AC-220
  • Lub npe:Quizartinib; AC-010220; AC-220
  • Catalog No.:PAB 0099
  • CAS Nr:.950769-58-1
  • Molecular Luj:560.673 ib
  • Tshuaj Formula:C29H32N6O4S
  • Rau kev tshawb fawb tshawb fawb nkaus xwb, tsis yog rau cov neeg mob.

    Product Detail

    Khoom cim npe

    Pob Loj Muaj Nqe (USD)
    5g Hauv Tshuag 1000
    10g ua Hauv Tshuag 1500
    Ntau qhov ntau thiab tsawg Tau txais Quotes Tau txais Quotes

    Lub npe tshuaj:

    N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl ]phenyl}urea

    SMILES Code:

    O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5))=CC=C34)=N2)C=C1)NC6=NOC(C)(C)C)=C6

    InChi Code:

    InChI = 1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22- 18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4- 9,16-18H, 10-15H2,1-3H3, (H2,30,32,33,36)

    InChi Key:

    CVWXJKQAOSCOAB-UHFFFAOYSA-N

    Lo lus tseem ceeb:

    Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1

    Solubility:Soluble hauv DMSO

    Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

    Nqe lus piav qhia:

    Quizartinib yog ib qho inhibitor ntawm FMS-txog tyrosine kinase 3 (FLT3; Kd = 1.6 nM) thiab ua kom pom kev xaiv siab rau FLT3 thaum kuaj tawm tsam ntawm 227 kinases ntxiv. Nws inhibits qhov kev loj hlob ntawm tib neeg leukemia cell kab MV4-11, uas harbors ib homozygous FLT3-ITD kev hloov, nrog rau IC50 tus nqi ntawm 0.56 nM.1 Ntawm 1 mg / kg / hnub, quizartinib tau pom tias kom muaj sia nyob ntev hauv nas. qauv ntawm FLT3-ITD mob myeloid leukemia thiab tshem tawm cov qog hauv FLT3-dependent nas xenograft qauv ntawm 10 mg / kg.

    Hom phiaj: FLT3


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