Advivint

Lub npe tshuaj:

N-(5-{3-[7-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl}pyridin-3-yl)-3 -methylbutanamide

SMILES Code:

CC(C)CC(NC1=CC(C2=CC3=C(NN=C3C(N4))=NC5=C4C(C6=CC=CC(F)=C6)=CN=C5)C2)=CN= C1) = O

InChi Code:

InChI=1S/C29H24FN7O/c1-16(2)8-26(38)33-21-10-19(12-31-13-21)17-6-7-24-22(11-17)28( 37-36-24) 29-34 ib 25-15-32-14-23(27(25)35-29)18-4-3-5-20(30)9-18/h3-7,9-16H,8H2,1-2H3,( H, 33, 38) (H, 34, 35) (H, 36, 37)

InChi Key:

AQDWDWAYVBQMAM-UHFFFAOYSA-N

Lo lus tseem ceeb:

Adavivint, SM04690, SM-04690, SM 04690, 1467093-03-3

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

Ib qho tshiab me me molecule Wnt pathway inhibitor nrog EC50 ntawm 3 nM hauv vitro; induces hMSC sib txawv rau hauv mature, functional chondrocytes thiab txo cov pob txha mos catabolic marker qib; Txhim kho Osteoarthritis Research Society International (OARSI) cov qhab nia histology thiab biomarkers hauv tus qauv nas OA.

Target: NWS