TIAB SA 7507

Lub npe tshuaj:

4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide

SMILES Code:

O=C(C1=NN=C2C=C(OC)C(N3CCN(CCO)CC3)=CC2=C1NC4=CC=C(C)C=C4F)N

InChi Code:

InChI=1S/C23H27FN6O3/c1-14-3-4-17(16(24)11-14)26-21-15-12-19(30-7-5-29(6-8-30)9- 10-31 : kuv 20(33-2)13-18(15)27-28-22(21)23(25)32/h3-4,11-13,31H,5-10H2,1-2H3,(H2,25, 32) (H, 26, 27) H.

InChi Key:

CPDGCAFPSYOTGO-UHFFFAOYSA-N

Lo lus tseem ceeb:

UAS 7507; AZD-7507; TIAB SA 7507

Solubility:DMSO

Cia: 

Nqe lus piav qhia:

AZD7507 yog ib qho muaj zog thiab xaiv CSF-1R inhibitor (32 nM ntawm tes ua haujlwm), AZD7507 yog suav tias yog ib qho kev cog lus zoo li nws khaws cia qhov xav tau potency thiab qhov ncauj pharmacokinetic zog ntawm AZ683. Ntxiv mus, hauv kev kawm telemetry hauv cov dev muab ib koob tshuaj ntawm qhov ncauj, tsis muaj kev mob plawv, tsis muaj kev nce siab ntawm troponin ntsig txog kev kho mob, thiab tsis muaj kev hloov pauv hauv ECG.

Hom phiaj: CSF-1R