Resmetirom

Inoa Kimia:

Resmetirom

SMILES Code:

N#CC1=NN(C2=CC(Cl)=C(OC(C=C3C(C)C)=NNC3=O)C(Cl)=C2)C(NC1=O)=O

Code InChi:

InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25- 17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27,28)

Ki InChi:

FDBYIYFVSAHJLY-UHFFFAOYSA-N

huaʻōlelo:

MGL-3196; MGL 3196; VIA 3196; VIA-3196; Resmetirom

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia i DMSO, ʻaʻole i ka wai

Waihona:0 - 4 C no ka wā pōkole (nā lā i nā pule), a i ʻole -20 C no ka wā lōʻihi (mau mahina)

wehewehe:

ʻO Resmetirom, ka mea i kapa ʻia ʻo MGL-3196, he mea ikaika a koho nui loa i ka thyroid hormone receptor β agonist i nā hoʻokolohua lapaʻau no ka mālama ʻana i ka dyslipidemia. ʻO nā hopena maikaʻi o ka hormone thyroid (TH) ma nā pae lipid ma muli o kāna hana ma ka thyroid hormone receptor β (THR-β) i loko o ke ake, aʻo nā hopena ʻino, me nā hopena cardiac, ua hoʻopili ʻia e ka thyroid hormone receptor α (THR). -α).

Pahuhopu: THR-β