Quarfloxin

Inoa Kimia:

5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl )-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide

SMILES Code:

FC1=C(N2CC[C@@H](C3=CN=CC=N3)C2)C(OC4=C5C=C6C(C=CC=C6)=C4)=C(N5C=C(C(NCC[ C@H]7N(C)CCC7)=O)C8=O)C8=C1

Code InChi:

InChI=1S/C35H33FN6O3/c1-40-13-4-7-24(40)8-10-39-35(44)26-20-42 -29-15-21-5-2-3-6-22(21)16-30(29)45-34-31(42)25(33(26)43)17-27 (36)32(34)41-14-9-23(19-41)28-18-37-11-12-38-28/h2-3,5-6,11-12 ,15-18,20,23-24H,4,7-10,13-14,19H2,1H3,(H,39,44)/t23-,24+/m1/s1

Ki InChi:

WOQIDNWTQOYDLF-RPWUZVMVSA-N

huaʻōlelo:

CX 3543; CX-3543; CX 3543; ʻO Quarfloxacin

Hiki ke hoʻoheheʻe: 

Waihona: 

wehewehe:

ʻO Quarfloxin, ka mea i kapa ʻia ʻo Quarfloxacin a me CX-3543, he fluoroquinolone derivative me ka hana antineoplastic. Hoʻopilikia ʻo Quarfloxin i ka pilina ma waena o ka protein nucleolin a me kahi ʻano G-quadruplex DNA i loko o ka ribosomal DNA (rDNA) template, kahi pilina koʻikoʻi no ka biogenesis rRNA i hōʻike nui ʻia i loko o nā pūnana maʻi maʻi; ka hoʻohaunaele ʻana i kēia G-quadruplex DNA: ʻo ka launa pū ʻana o ka protein i ka aberrant rRNA biogenesis hiki ke hopena i ka pale ʻana o ka ribosome synthesis a me ka apoptosis cell tumor.

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