| CAT # | Inoa Huahana | wehewehe |
| CPD100608 | ASK1-Inhibitor-10 | ʻO ka ASK1 Inhibitor 10 he mea hoʻopaneʻe waha bioavailable o ka apoptosis hōʻailona-hoʻoponopono kinase 1 (ASK1). He koho ia no ASK1 ma luna o ASK2 a me MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, a me B-RAF. Kāohi ia i ka piʻi ʻana o ka streptozotocin-induced i ka JNK a me ka p38 phosphorylation i loko o INS-1 pancreatic β cell ma kahi ʻano hilinaʻi. |
| CPD100607 | K811 | ʻO K811 kahi mea hoʻopaneʻe kikoʻī ASK1 e hoʻolōʻihi i ke ola ʻana i kahi ʻano ʻiole o ka amyotrophic lateral sclerosis. Kāohi maikaʻi ʻo K811 i ka hoʻonui ʻana o ke kelepona ma nā laina kelepona me ka hōʻike ASK1 kiʻekiʻe a ma nā pūnaewele GC-overexpressing HER2. ʻO ka lapaʻau ʻana me K811 i hoʻemi ʻia ka nui o nā maʻi maʻi xenograft ma o ka hoʻohaʻahaʻa ʻana i nā hōʻailona proliferation. |
| CPD100606 | K812 | ʻO K812 kahi mea hoʻopaneʻe kikoʻī ASK1 i ʻike ʻia e hoʻolōʻihi i ke ola ʻana i kahi ʻano ʻiole o ka amyotrophic lateral sclerosis. |
| CPD100605 | MSC-2032964A | ʻO MSC 2032964A kahi mea hoʻokae ASK1 ikaika a koho (IC50 = 93 nM). Hoʻopaʻa ia i ka LPS-induced ASK1 a me ka p38 phosphorylation i nā astrocytes ʻiole moʻomeheu a hoʻopau i ka neuroinflammation i kahi kiʻi EAE kiʻi. ʻO MSC 2032964A ka mea hiki ke loaʻa i ka waha a me ka lolo. |
| CPD100604 | Selonsertib | ʻO Selonsertib, ka mea i kapa ʻia ʻo GS-4997, he mea hoʻopiʻi waha bioavailable o ka apoptosis signal-regulating kinase 1 (ASK1), me nā hana anti-inflammatory, antineoplastic a me nā hana anti-fibrotic. ʻO GS-4997 nā pahuhopu a hoʻopaʻa i ka catalytic kinase domain o ASK1 ma kahi ʻano hoʻokūkū ATP, no laila e pale ai i kāna phosphorylation a me ka hoʻāla ʻana. Kāohi ʻo GS-4997 i ka hana ʻana o nā cytokine inflammatory, hoʻoponopono i ka hōʻike ʻana o nā genes i komo i ka fibrosis, hoʻopau i ka apoptosis nui a keʻakeʻa i ka hoʻonui ʻana o ka cellular proliferation. |
