BMS-986195

Inoa Kimia:

(S)-4-(3-(akā-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide

SMILES Code:

FC1=C(N2CCC[C@H](NC(C#CC)=O)C2)C3=C(NC(C)=C3C)C(C(N)=O)=C1

Code InChi:

InChI=1S/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18- 17(19)11(2)12(3)23-18/h9,13,23H,5,7-8,10H2,1-3H3,(H2,22,27)(H,24,26)/t13 -/m0/s1

Ki InChi:

VJPPLCNBDLZIFG-ZDUSSCGKSA-N

huaʻōlelo:

BMS-986195, BMS 986195, BMS986195, 1912445-55-6

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

ʻO BMS-986195 he mea hoʻopaneʻe ikaika, covalent, hiki ʻole ke hoʻololi ʻia o ka tyrosine kinase (BTK) o Bruton, he lālā o ka ʻohana Tec o nā kinases tyrosine non-receptor pono i ka hōʻailona B-cell pili antigen a me ka hana. ʻOi aku ka BMS-986195 ma mua o 5000-fold i koho ʻia no BTK ma luna o nā kinase āpau ma waho o ka ʻohana Tec, a ʻo ka koho koho mai 9- a hiki i 1010-fold i loko o ka ʻohana Tec. BMS-986195 inactivated BTK i loko o ke kanaka holoʻokoʻa koko me ka wikiwiki o ka inactivation (3.5×10-4 nM-1·min-1) a potently inhibited antigen-hilinaʻi interleukin-6 hana, CD86 hōʻike a me ka proliferation i loko o B (IC50).<1 nM) me ka ʻole o ka hopena i nā ana antigen-kūʻokoʻa i loko o nā pūnaewele like.

Pahuhopu: BTK