BI-2852

Inoa Kimia:

(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methyl)amino)methyl) -1H-indol-3-yl)isoindolin-1-kahi

SMILES Code:

OC(C=C1)=CC([C@@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62) N7)=C1C7=O

Code InChi:

InChI=1S/C31H28N6O2/c1-36-16-21(33-18-36)17-37-11-10-20-7-6-19(12-28(20)37)14-32-15- 27-29(24-4-2-3-5-26(2 4)34-27)30-25-13-22(38)8-9-23(25)31(39)35-30/h2-13,16,18,30,32,34,38H,14- 15,17H2,1H3,(H,35,39)/t30-/m0/s1

Ki InChi:

JYEQLXOWWLNVDX-PMERELPUSA-N

huaʻōlelo:

Hiki ke hoʻoheheʻe: 

Waihona: 

wehewehe:

ʻO BI-2852 kahi mea hoʻopaneʻe KRAS ikaika e hoʻopaʻa me ka pili nanomolar i kahi ʻeke, a hiki i kēia manawa ke ʻike ʻia he "unruggable," ma waena o ka hoʻololi I a me II ma RAS. He ʻokoʻa loa ka BI-2852 mai nā mea hoʻopaneʻe kovalent KRASG12C no ka mea e hoʻopaʻa ʻia i kahi ʻeke ʻokoʻa i loaʻa i nā ʻano hana a me nā ʻano hana ʻole o KRAS. Hoʻopili ʻo BI-2852 i ka GEF, GAP, a me ka hopena hopena me KRAS, e alakaʻi ana i ka pale ʻana i ka hōʻailona o lalo a me ka hopena antiproliferative i nā pūnaewele mutant KRAS.

Pahuhopu: KRAS