AZD-3409

Inoa Kimia:

(S)-isopropyl 2-(2-(4-fluorophenethyl)-5-((((2S,4S))-4-(nicotinoylthio)pyrrolidin-2-yl)methyl)amino)benzamido)-4-(methylthio) butanoate

SMILES Code:

O=C(OC(C)C)[C@@H](NC(C1=CC(NC[C@H]2NC[C@@H](SC(C3=CN=CC=C3)=O) C2)=CC=C1CCC4=CC=C(F)C=C4)=O)CCSC

Code InChi:

InChI=1S/C34H41FN4O4S2/c1-22(2)43-33(41)31(14-16-44-3)39-32(40)30-18-27(13-10-24(30)9- 6-23-7-11-26(35)12-8-23)37-20-28-17-29(21-38-28)45-34(42)25-5-4-15-36- 19-25/h4-5,7-8,10-13,15,18-19,22,28-29,31,37-38H,6,9,14,16-17,20-21H2,1- 3H3,(H,39,40)/t28-,29-,31-/m0/s1

Ki InChi:

HKGUHEGKBLYKHY-QMOZSOIISA-N

Hua'ōlelo:

AZD3409; AZD-3409; AZD 3409

Hiki ke hoʻoheheʻe: 

Waihona: 

wehewehe:

ʻO AZD-3409 kahi mea paʻa prenyl transferase. Ua hōʻike ʻo AZD-3409 i ka mana kiʻekiʻe ma mua o lonafarnib. ʻO ka mean IC (50) no ka cytotoxicity o AZD3409 he 510 i loko o nā pūnaewele MEF, 10,600 i nā pūnaewele A549 a me 6,170 i nā pūnaewele MCF7, kēlā me kēia. I loko o kēia mau pūnaewele, ʻo ka IC (50) no ka hana FTase o AZD3409 mai 3.0 a 14.2 nM a me lonafarnib mai 0.26 a 31.3 nM. Kāohi ʻo AZD3409 i ka farnesylation i kahi kiʻekiʻe ma mua o ka geranylgeranylation. ʻAʻole hiki ke hoʻopili ʻia ka pale ʻana o ka farnesylation a me ka geranylgeranylation i ka hana antiproliferative o ka lāʻau. Hiki paha iā AZD3409 ke ʻeleu i ka maʻi maʻi maʻi umauma gefitinib.

Pahuhopu: prenyl transferase inhibitor