Saukewa: SB-204990

Sunan Sinadari:

trans-5-[6- (2,4-Dichlorophenyl) hexyl] tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

Lambar SMILES:

O=C(O)C[C@@]1(O)C(O[C@H](CCCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

Lambar InChi:

InChi=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,1) 1-16 (21)22)17 (23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18-/m1/s1

InChi Key:

YTRNLFYTHYWDAU-RDTXWAMCSA-N

Mabuɗin kalma:

SB-204990, SB 204990, SB204990

Solubility: 

Ajiya: 

Bayani:

SB-204990 shine prodrug na m ATP citrate-lyase inhibitor SB-201076. SB-204990, lokacin da aka ba da baki ga berayen, an nutsar da shi a cikin tsarin wurare dabam dabam, an dawo da matakan da suka dace na SB-201076 a cikin hanta. SB-204990 (25 mg/kg a kowace rana) kuma ya rage matakan cholesterol na plasma (har zuwa 23%) da matakan triglyceride (har zuwa 38%) a cikin kare, wanda zai fi dacewa rage ƙarancin lipoprotein mai yawa idan aka kwatanta da babban cholesterol na lipoprotein mai yawa. matakan. SB-204990 yana da mahimmancin enzyme a cikin sarrafa kayan da aka samar don haɓakar lipid de novo da yuwuwar manufar enzyme don shiga tsakani na hypolipidaemic.

Manufar: