ATP citrate-lyase

CAT #	Sunan samfur	Bayani
Saukewa: CPD3611	Saukewa: SB-204990	SB-204990 shine prodrug na m ATP citrate-lyase inhibitor SB-201076. SB-204990, lokacin da aka ba da baki ga berayen, an nutsar da shi a cikin tsarin wurare dabam dabam, an dawo da matakan da suka dace na SB-201076 a cikin hanta. SB-204990 (25 mg/kg a kowace rana) kuma ya rage matakan cholesterol na plasma (har zuwa 23%) da matakan triglyceride (har zuwa 38%) a cikin kare, wanda zai fi dacewa rage ƙarancin lipoprotein mai yawa idan aka kwatanta da babban cholesterol na lipoprotein mai yawa. matakan. SB-204990 yana da mahimmancin enzyme a cikin sarrafa kayan da aka samar don haɓakar lipid de novo da yuwuwar manufar enzyme don shiga tsakani na hypolipidaemic.