Saukewa: IACS-010759
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 100mg | A Stock | 300 |
| 500mg | A Stock | 800 |
| 1g | A Stock | 1200 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
5- (5-methyl-1- (3- (4- (methylsulfonyl)) piperidin-1-yl) benzyl) -1H-1,2,4-triazol-3-yl) -3- (4- (trifluoromethoxy) phenyl -1,2,4-oxadiazole
Lambar SMILES:
FC(F)(F) OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC(N5CCC(S(=O)) N3)=N2)C=C1
Lambar InChi:
InChi=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28) 31-34 (16)15-17-4-3-5-19 (14-17)33-12-10-21 (11-13-33)39 (2,35)36/h3-9,14, 21H, 10-13,15H2,1-2H3
InChi Key:
HWJWNWZJUYCGKV-UHFFFAOYSA-N
Mabuɗin kalma:
IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).
Bayani:
IACS-010759 ko IACS-10759 mai ƙarfi ne kuma zaɓi Inhibitor Oxidative Phosphorylation (IC50)<10 nM) tare da yuwuwar aikin antineoplastic. IACS-010759 yana ɗaure kuma yana hana hadaddun I na sarkar jigilar lantarki (NADH ubiquinone oxidoreductase), ta haka zaɓen yana hana ƙwayoyin tumor abubuwan gina jiki, da kuzari, da hana samar da nucleotide da amino acid, wanda ke haifar da autophagy, yana haifar da mutuwar ƙwayar cuta kuma yana hana tantanin halitta. yaduwa. Mitochondrial hadaddun I, wanda aka hyperactivated a cikin ciwon daji Kwayoyin don biyan buƙatun su na makamashi, yana taka muhimmiyar rawa wajen inganta yaduwar kwayar cutar kansa.
Manufar: OXPHOS