Saukewa: BI-2852

Sunan Sinadari:

(S) -5-hydroxy-3- (2-(((1- ((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methyl)amino) methyl) -1H-indol-3-yl) isoindolin-1-daya

Lambar SMILES:

OC(C=C1)=CC([C@@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62) N7)=C1C7=O

Lambar InChi:

InChi=1S/C31H28N6O2/c1-36-16-21(33-18-36)17-37-11-10-20-7-6-19(12-28(20)37)14-32-15- 27-29 (24-4-2-3-5-26(2 4)34-27)30-25-13-22(38)8-9-23(25)31(39)35-30/h2-13,16,18,30,32,34,38H,14- 15,17H2,1H3,(H,35,39)/t30-/m0/s1

InChi Key:

JYEQLXOWWLNVDX-PMERELPUSA-N

Mabuɗin kalma:

Solubility: 

Ajiya: 

Bayani:

BI-2852 shine mai hanawa KRAS mai ƙarfi wanda ke ɗaure tare da kusancin nanomolar zuwa aljihu, wanda ya zuwa yanzu ana ganin ya zama "marasa ƙarfi," tsakanin sauyawa I da II akan RAS. BI-2852 ya bambanta da injiniyoyi daga masu hana masu hanawa KRASG12C saboda yana ɗaure ga wani aljihu daban wanda ke cikin duka nau'ikan KRAS masu aiki da marasa aiki. BI-2852 yana toshe GEF, GAP, da ma'amala mai tasiri tare da KRAS, yana haifar da hana siginar ƙasa da tasirin antiproliferative a cikin ƙwayoyin mutant KRAS.

manufa: KRAS