Sildenafil chiotráite

Ainm Cheimiceach:

5-(2-eatocsa-5-((4-meitilpiperazin-1-il)sulfónail)feinil)-1-meitil-3-próipil-1,4-dé-hidr-7H-piorasóil[4,3-d]pirimidin- 7-aon 2-hydroxypropane-1,2,3-tricarboxylate

Cód Smiles:

"CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)CC(C(=O)O )C(CC(=O)O)(C(=O)O)O"

Cód InChi:

InChI=1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9- 18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;7-3(8)1-6(13,5(11)12) 2-4(9)10/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)( H,9,10)(H,11,12)

Eochair InChi:

DEIYFTQMQPDXOT-UHFFFAOYSA-N

Eochairfhocal:

Sildenafil chiotráite；UK 92480-10；UK-92,480-10； Athbheochan； VIAGRA；171599-83-0；CAS:171599-83-0；CAS:171599-83-0

Tuaslagthacht:Intuaslagtha i DMSO

Stóráil:0 - 4°C don ghearrthéarma (laethanta go seachtainí), nó -20°C don fhadtéarma (míonna)

Cur síos:

Is foirm chiotráite de Sildenafil é sildenafil, citrate. Is inhibitor roghnach de PDE5 (cGMP phosphodiesterase cineál 5) é Sildenafil a chatalaíonn hidrealú monafosfáit guanóisín 3',5'-timthriallach (cGMP). Mar choscóir PDE5, tá sé tuairiscithe go gcuireann Sildenafil feabhas ar neuro-, synapto- agus angiogenesis i múnlaí stróc francach agus tuairiscítear gur vasodilator éadrom é freisin. Taispeánadh freisin go gcuireann Sildenafil cosc ​​​​ar fhoirmiú beag ulceration intestinal de bharr indomethacin trí mheicníocht a bhraitheann NO/cGMP.

Sprioc: PDE5