S-600918, Sivopixant

Ainm Cheimiceach:

(2S)-3-[(4E)-3-[(4-clórafeinil)meitil]-2,6-dé-ocsa-4-({4-[(piridin-2-il)ocsa]feinil}imín)-1 ,3,5-triazinan-1-il]-2-aigéad meitiolprópánóch

Cód Smiles:

O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC =CC=C4)C=C3)=O

Cód InChi:

InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17)28-1 9-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H,32,33)( H,28,29,34)/t16-/m0/s1

Eochair InChi:

SKZQFKBIJUXXCG-INIZCTEOSA-N

Eochairfhocal:

2414285-40-6; CAS: 2414285-40-6; CAS:2414285-40-6; Sivopixant; S-600918; S 600918; S600918

Tuaslagthacht:Intuaslagtha i DMSO

Stóráil:Tirim, dorcha agus ag 0 - 4 C go gearrthéarmach (laethanta go seachtainí) nó -20 C go fadtéarmach (mí go blianta)

Cur síos:

Is antagonist receptor P2X3 roghnach é Sivopixant, ar a dtugtar S-600918 freisin (P2X3 IC50, 4.2 nM; P2X2 / 3 IC50, 1100 nM). Léirigh Sivopixant éifeacht analgesic láidir i múnla ligation nerve sciatic páirteach francach (múnla Seltzer) de allodynia (ED50, 0.4 mg/kg).

Sprioc: Frithghníomhaí receptor P2X3 roghnach