| # CAT | Ainm Táirge | Cur síos |
| TCP3611 | SB-204990 | Is é SB-204990 táirge an inhibitor citrate-lyase ATP cumhachtach SB-201076. Glacadh SB-204990, nuair a thugtar é ó bhéal do francaigh, isteach sa scaipeadh sistéamach, aisghabhadh tiúchain ábhartha cógaseolaíochta de SB-201076 san ae. Laghdaigh SB-204990 (25 mg / kg in aghaidh an lae) leibhéil colaistéaról plasma (suas le 23%) agus leibhéil tríghlicríde (suas le 38%) sa madra, ag laghdú go tosaíochta lipoprotein ísealdlúis i gcomparáid le colaistéaról lipoprotein ard-dlúis. leibhéil. Is einsím thábhachtach é SB-204990 maidir le soláthar substráit a rialú do shintéis lipid de novo agus sprioc einsím féideartha d’idirghabháil hypolipidaemic. |
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