Luxdegalutamide; ARV-766

Ainm Cheimiceach:

4-(4-((1-(4-(((1r,3r))-3-(4-ciano-3-methocsaifeinocsa)-2,2,4,4-tetramethylcyclobutyl)carbamoyl)feanil)piperidin-4- yl)meitil)piperazin-1-il)-N-((S)-2,6-dé-ocsaipéiridin-3-il)-2-fluaraibeinsimíd

Cód Smiles:

CC1(C)[C@H](NC(C2=CC=C(N3CCC(CN4CCN(C5=CC(F))=C(C(N[C@H]6C(=O)NC(=O)) CC6)=O)C=C5)CC4)CC3)C=C2)=O)C(C)(C)(C)[C@H]1OC1=CC(OC)=C(C#N)C=C1

Cód InChi:

InChI=1S/C45H54FN7O6/c1-44(2)42(45(3,4)43(44)59-33-12-8-30(26-47)37(25-33)58-5)50- 39(55)29-6-9-31(10-7-29)52-18-16-28(17-19-52)27-51-20-22-53(23-21-51)32- 11-13-34(35(46)24-32)40(56)48-36-14-15-38(54)49-41(36)57/h6-13,24-25,28,36, 42-43H,14-23,27H2,1-5H3,(H,48,56)(H,50,55)(H,49,54,57)/t36-,42-,43-/m0/s1

Eochair InChi:

RDPPBRKNBBXPNZ-FMPIRMQTSA-N

Eochairfhocal:

2750830-09-0 ；CAS: 2750830-09-0 ； CAS: 2750830-09-0；ARV766; ARV 766; ARV-766; GTPL12624; luxdegalutamide

Tuaslagthacht: 

Stóráil:Tirim, dorcha agus ag 0 - 4 C go gearrthéarmach (laethanta go seachtainí) nó -20 C go fadtéarmach (mí go blianta).

Cur síos:

Is éard atá i Luxdegalutamide (ARV-766) hidrealú próitéine dírithe ar chimeric (PROTAC) ó bhéal a dhíríonn ar receptor androgen (AR), ar féidir leis mutants a bhaineann le friotaíocht AR a dhíghrádú.

Sprioc: AR