GDC6036; GDC6036 atrapisiméirí

Ainm Cheimiceach:

2-Propen-1-aon, 1-[(3S)-4-[7-[6-aimín-4-meitil-3-(trífhluaramethyl)-2-piridinil]-6-clóra-8-fluara-2- [[(2S)-1-meitil-2-pirrolidinil]meitile]-4-quinazolinil]-3-meitil-1-piperazinil]-

Cód Smiles:

C=CC(N1C[C@H](C)N(C2=C3C=C(Cl)C(C4=NC(N)=CC(C)=C4C(F)(F)F)=C(F) )C3=NC(OC[C@H]5N(C)CCC5)=N2)CC1)=O

Cód InChi:

InChI=1S/C29H32ClF4N7O2/c1-5-21(42)40-9-10-41(16(3)13-40)27-18-12-19(30)22(26-23(29(32, 33)34)15(2)11-20(35)36-2 6)24(31)25(18)37-28(38-27)43-14-17-7-6-8-39(17)4/h5,11-12,16-17H,1,6- 10,13-14H2,2-4H3,(H2,35,36)/t16-,17-/m0/s1

Eochair InChi:

ZRBPIAWWRPFDPY-IRXDYDNUSA-N

Eochairfhocal:

2417917-17-8 ；CAS: 2417917-17-8； CAS: 2417917-17-8 ； GDC6036 atropisomers; GDC-6036; GDC 6036; GDC6036

Tuaslagthacht: 

Stóráil:Tirim, dorcha agus ag 0 - 4 C go gearrthéarmach (laethanta go seachtainí) nó -20 C go fadtéarmach (mí go blianta).

Cur síos:

Tá dhá chineál isiméirí frith-uainíochta GDC6036 san isiméir frith-uainíochta GDC6036. GDC-6036, Ar a dtugtar RG6330 freisin, is inhibitor KRAS G12C bith-infhaighte ó bhéal, an-éifeachtach agus roghnach.

Sprioc: KRAS G12C