Ziftomenib;KO539

Igama:(S)-4-Methyl-5-((4-(2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno(2,3-d)pyrimidin-4-yl)amino)piperidin -1-yl) methyl)-1-(2-(4-(methylsulfonyl)piperazin-1-yl)propyl)-1H-indole-2-carbonitrile

Inombolo yekhathalogu:CPD113642

Inombolo yeCAS:2134675-36-6

Ubunzima beMolekyuli:717.87

Ifomula yemichiza:C33 H42 F3 N9 O2 S2

Kuphando lwenzululwazi kuphela, hayi izigulane.

Thumela i-imeyile kuthi Khuphela njengePDF

Iinkcukacha zeMveliso

Iithegi zeMveliso

Ubungakanani bePakethe	Ubukho	Ixabiso (USD)
0.1G	Ikhona evenkileni	650
0.5G	Ikhona evenkileni	970
1G	Ikhona evenkileni	1350

Igama leMchiza:

(S)-4-Methyl-5-((4-(2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno(2,3-d)pyrimidin-4-yl)amino)piperidin -1-yl) methyl)-1-(2-(4-(methylsulfonyl)piperazin-1-yl)propyl)-1H-indole-2-carbonitrile

Ikhowudi yoncumo:

N#CC(N1C[C@@H](N2CCN(S(=O)(C)=O)CC2)C)=CC3=C1C=CC(CN4CCC(NC5=C(C=C(CC(F)) (F)F)S6)C6=NC(NC)=N5)CC4)=C3C

Ikhowudi ye-InChi:

InChI=1S/C33H42F3N9O2S2/c1-21(43-11-13-44(14-12-43)49(4,46)47) 19-45-25(18-37)15-27-22(2)23(5-6-29(27)45)20-42-9-7-24(8-10-42) ) 39-30-28-16-26(17-33(34,35)36)48-31(28)41-32(38-3)40-30/h5-6, 15-16,21,24H,7-14,17,19-20H2,1-4H3,(H2,38,39,40,41)/t21-/m0/s1

Isitshixo se-InChi:

BGGALFIXXQOTPY-NRFANRHFSA-N

Igama elingundoqo:

2134675-36-6 ;CAS:2134675-36-6;CAS:2134675-36-6;Ziftomenib; KO539; KO 539; KO-539

Ukunyibilika:Ukuba kuqikelelwe

Ugcino:Yomile, emnyama kunye ne-0 - 4 C kwixesha elifutshane (iintsuku ukuya kwiiveki) okanye -20 C ixesha elide (iinyanga ukuya kwiminyaka).

Inkcazo:

I-Ziftomenib (KO-539) yi-inhibitor ye-menin ye-MLL yokusebenzisana nomsebenzi womlomo.

Ithagethi: i-menin-MLL

Ngaphambili: 4,6-dichloro-5-fluoro-2-Methanesulfonyl-pyriMidine

Okulandelayo: N-Methyl-5-(piperazin-1-yl)picolinamide hydrochloride