I-Sildenafil Citrate

Igama leMchiza:

5-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin- I-7-enye i-2-hydroxypropane-1,2,3-tricarboxylate

Ikhowudi yoncumo:

"CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)CC(C(=O)O )C(CC(=O)O)(C(=O)O)O "

Ikhowudi ye-InChi:

InChI=1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9- 18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;7-3(8)1-6(13,5(11)12) 2-4(9)10/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)( H,9,10)(H,11,12)

Isitshixo se-InChi:

DEIYFTQMQPDXOT-UHFFFAOYSA-N

Igama elingundoqo:

Sildenafil Citrate;UK 92480-10;UK-92,480-10; Revatio; VIAGRA;171599-83-0;CAS:171599-83-0;CAS:171599-83-0

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)

Inkcazo:

I-Sildenafil, i-Citrate yindlela ye-citrate ye-Sildenafil. I-Sildenafil i-inhibitor ekhethiweyo ye-PDE5 (uhlobo lwe-5 cGMP phosphodiesterase) eyenza i-hydrolysis ye-3 ',5'-cyclic guanosine monophosphate (cGMP). Njenge-PDE5 inhibitor, i-Sildenafil iye yaxelwa ukuba iphucule i-neuro-, i-synapto- kunye ne-angiogenesis kwiimodeli zegundane ze-stroke kwaye kuxelwe ukuba yi-vasodilator epholileyo. I-Sildenafil nayo ibonakaliswe ukukhusela i-indomethacin-induced intestinal ulceration formation ngokusebenzisa indlela exhomekeke kwi-NO / cGMP.

Ithagethi: PDE5