S-600918,Sivopixant

Igama leMchiza:

(2S)-3-[(4E)-3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-({4-[(pyridin-2-yl)oxy]phenyl}imino)-1 ,3,5-triazinan-1-yl] -2-methylpropanoic acid

Ikhowudi yoncumo:

O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC =CC=C4)C=C3)=O

Ikhowudi ye-InChi:

InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17)28-1 9-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H,32,33)( H,28,29,34)/t16-/m0/s1

Isitshixo se-InChi:

SKZQFKBIJUXXCG-INIZCTEOSA-N

Igama elingundoqo:

2414285-40-6; I-CAS: 2414285-40-6; I-CAS: 2414285-40-6; iSivopixant; S-600918; S 600918; S600918

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:Yomile, emnyama kunye ne-0 - 4 C kwixesha elifutshane (iintsuku ukuya kwiiveki) okanye -20 C ixesha elide (iinyanga ukuya kwiminyaka)

Inkcazo:

I-Sivopixant, eyaziwa ngokuba yi-S-600918, i-P2X3 receptor antagonist ekhethiweyo (P2X3 IC50, 4.2 nM; P2X2 / 3 IC50, 1100 nM). I-Sivopixant ibonise umphumo onamandla we-analgesic kwi-rat partial partial sciatic nerve ligation model (imodeli ye-Seltzer) ye-allodynia (ED50, 0.4 mg / kg).

Ithagethi: I-P2X3 ekhethiweyo ye-receptor antagonist